At the Indiana Center for Regenerative Medicine and Engineering, scientists and clinicians work with government organizations as well as industry to address pressing military and veteran needs related to limb loss and other complex issues. The primary goal is to help military personnel lead productive lives comparable to non-amputees. An important secondary goal is enabling return of affected personnel to active duty status.
Prosthetics and regenerative rehabilitation
Current patient-based research at the Indiana Center for Regenerative Medicine and Engineering employs in-socket diagnostics and imaging to critically assess limb health. The program has the ability to monitor and manage limb volume, limb temperature, and other vital health outcomes, which significantly inform advancements in prosthetic technology, resections, and performance outcomes.
A range of non-invasive imaging technologies are employed to assess the impact of prosthetics. Such approaches promise unparalleled user experiences and outcomes. The use of targeted muscle reinnervation and targeted sensory reinnervation is enabling the development of very advanced bionic systems. Additionally, imaging approaches such as shape capture are being used to better understand how residual limbs interact with prosthetic systems.
Military servicemen and servicewomen have distinctly different prosthetic needs. Our sex-based research considers unique anatomical and other characteristics to develop solutions specifically suited for women. Aesthetics is an important consideration in this approach. The goal is to maintain and improve residual limb health across a lifetime, coupled with the need to push boundaries in terms of durability, functionality, and performance.
Our focus is to take solutions to people, and optimal industry partnerships represent a major cornerstone of our work. For example, a VA-funded project focused on developing an adaptive socket system that optimizes fit and performance went to market two years after inception and is currently used by veterans.
As an emerging field, regenerative rehabilitation integrates regenerative medicine and rehabilitation sciences to develop innovative solutions. Current research aims to investigate cell-based therapies, tissue engineering, and novel regenerative processes that may improve residual limb health and prosthetic performance. Large animal studies as well as patient-based studies are currently ongoing. Non-invasive imaging plays a major role in this pursuit.
Tien-Min Gabriel Chu
Professor, Associate Dean for Research
Regenerative rehabilitation, osteopenia, and fracture healing
Jeffrey A. Denune
Advanced prosthetic technology, CAD, CAM, 3D printing, bionic technology
Associate Professor of Surgery
Prosthetics, neurodegeneration, brain injury, repair, and glutamate metabolism in stroke
Gayle M. Gordillo
Professor of Surgery
Thermal burns, oxygen imaging, vascular, nutritional interventions, vascular anomalies, wound care
Regenerative rehabilitation and Applied Regenerative Medicine Lab
Skeletal development, age-related loss in bone and skeletal muscle mass, pathogenesis of pulmonary hypertension
Todd O. McKinley
Professor of Orthopaedic Surgery
Orthopaedic surgery, polytrauma, pelvic and acetabular surgery, infection
Professor of Surgery
Wound inflammation, mechanisms of wound infection, tissue repair, and cellular plasticity
Chandan K. Sen
Prosthetics, tissue injury and repair, tissue reprogramming, cutaneous wound healing, regenerative rehabilitation, infection management
Mechanotherapy on bone cell differentiation and regeneration
Associate Director, Biomedical Engineering, ICRME
Assistant Professor of Surgery
Nanotechnology/fabrication/sensors and biomedical engineering
Mervin C. Yoder
Director Emeritus, ICRME
Molecular mechanisms of endothelial progenitor cells in acute kidney injury and hyperoxic lung injury
Brent D. Toto
ICRME Center strategy and operations, Department of Defense and industry liaison