August 29, 2022 - Podcast

Episode 300 — Role of motion in DNA repair and damage response

DNA damage happens naturally in human body and most of the damage can be repaired by the cell itself. However, unsuccessful repair could lead to cancer. A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment. Their findings were recently published in the Proceedings of the National Academy of Sciences. IU Physics Professor Jing Liu and his colleagues found that chromatin on the site of DNA damage moves much faster than those away from the DNA damage. They also found that the chromatin in cell nuclei is not moving randomly. It’s a coherent movement, with the DNA moving as a group over a short distance. The researchers also found evidence that DNA damage may affect the DNA’s group movement by reducing the coherence. These findings indicate that chromatin motion is under tight control when DNA is damaged. This is important to prevent the damaged DNA from harmful contact and to improve the accuracy and efficacy of DNA repair. Liu says their findings reveal a fundamental role of the chromatin motion in DNA damage response and DNA repair, which can help researchers better understand the mechanism of DNA repair in human cells and cancer initiation in humans. He says these findings can also be used as the metrics for the drug response of many different drugs used to treat cancer. In the future, the researchers hope to study single DNA molecules and how they are moving, and how individual and group dynamics differ and change in response to DNA damage. Liu says they’d also like to learn more about DNA movement in specific genes that are known to be more vulnerable to DNA damage.